27 Dec Elective Single Embryo Transfer (eSET) : An advanced IVF technique
In the early days of IVF, replacement of several embryos in order to compensate for low implantation rates in human was considered good clinical practice. Lack of funding, sub optimal embryo culture and selection techniques and pressure from patients led to a staggering 50% of all children born after IVF / ICSI belong to a set of multiples.
High order multiple pregnancy (three or more implanted embryos) is an undesirable consequence of assisted reproduction techniques (ART). Multiple gestations lead to an increased risk of complication in both the foetus and mother. It is becoming gradually accepted that the incidence of iatrogenic twinning should be kept within reasonal limits.
In an effort to reduce the incidence of high order multiple gestations and promote singleton gestation, the concept of single embryo transfer is a very good approach. Elective Single Embryo Transfer (eSET) is when a woman undergoing IVF chooses to have a single embryo transferred when multiple embryos are available.
Recent advances in the embryo culture and selection techniques are now enabling the IVF expert to select and transfer one high quality embryo instead of two or more average quality embryos. The cumulative pregnancy rate has significantly increased due to this with considerable lowering of multiple order pregnancies. The advent of Advanced Embryo Selection (Array C G H) which is a PGD (pre implantation genetic diagnosis) technique has further improved the success. Moreover, the advancement in cryopreservation techniques enables to freeze the embryos and do a subsequent transfer with good success rate.
Thus, it has been argued that in near future, eSET should be the default policy on a global scale and we too should welcome the evolution. We at W Pratiksha Hospital are already working on this technique and it has brought about good results for all our patients.
Dr. Pramod Sharma
Chairman & Director
Pratiksha Group of Hospitals